That didn't work for me.
On the second day of classes I took notes in Word.
That worked out better.
On the third day of classes, I downloaded the OneNote 2007 beta and have been using OneNote ever since.
(So yes, when outlining for my first semester, it was a little harrowing, having to go hunt down my first week's notes from 3 different places.)
Try them all and go with whatever you find best for you. There isn't a right answer to this. I have classmates that exclusively take notes by hand, others that use word, and others like me, that use OneNote. They all do just fine.