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I'm a law student and got a full-time offer from a relatively prestigious litigation boutique. They've offered to let me work in their main office in a primary market (~30 attorneys) or one of their other offices in a secondary market (~5 attorneys). For lifestyle reasons, I would definitely prefer to work at their office in their secondary market. The hours are better and the money goes way further. Are there any reasons I shouldn't work at the secondary market office? I have only very modest ties to the region (though admittedly have comparable ties to the primary market).

I honestly would be wary about working at the smaller, secondary market office, especially early in your career. At that point, it is really important to build relationships, and you'll likely have an easier time doing that with a wider range of attorneys in the main office. Plus, even though the main office is larger, it's still small enough to get to know people quite well.