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Quick question (probably a dumb one): I'm going to an interview in NYC on Friday, and will be visiting friends in the area on the weekend, thus I'll probably have like a duffle bag and and backpack. But, I wont have time to drop off my stuff before my interview. Is it okay to politely ask the front desk to hold my bags as I interview?

You can either leave it at reception, or at your hotel front desk (even after checkout)

I'm not going to a hotel. I'm arriving in town right before my interview.