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I have already sent one LOCI to each of the schools i am interested in but still on the waitlist at. As the deposit deadlines approach in april, when is the best time to send a new loci (in which i have something impressive that i've received that i can write about)/new LOR, so that it has the full impact on the admissions committees for after the deposit deadlines for when they might start taking people off the waitlist. Is it better to just do it now or to wait until right before april 1 or april 15 depending on the school? Thanks.

I'm not an expert on this, but I think you should send it now.

The more you wait, the more you run the risk of a decision being rendered without the valuable info in their hands.